To worship God in spirit and truth means to worship God as we ought to worship Him. God is Spirit, so we must worship Him in spirit and truth, that is, by a humble and true adoration of spirit in the depth and center of our souls. God alone can see this worship; we can repeat it so often that in the end it becomes as if it were natural to us, and as if God were one with our souls, and our souls one with Him.
The circumstances and events that we see as setbacks are oftentimes the very things that launch us into periods of intense spiritual growth. Once we begin to understand this, and accept it as a spiritual fact of life, adversity becomes easier to bear.
Evildoers delight in hiding themselves; shun appearing; are bewildered when discovered; being accused, deny; not even when tortured, readily or always confess; certainly mourn when condemned; sum up against themselves, impute either to fate or to the stars the impulses of a wicked mind; for they will not have that to be their own, which they acknowledge to be evil. But what doth the Christian like this? None is ashamed, none repenteth, save that he was not such long ago. If he be marked down, he glorieth; if accused, maketh no defense; being questioned, confesseth even of his own accord; being condemned, giveth thanks. What manner of evil is this, which hath not the natural marks of evil, fear, shame, shrinking, penitence, sorrow? What manner of evil is this, whereof he that is accused rejoiceth?
We don't always need to know where we are going as long as we know whom we are following. God is in control. Even when we wind up in strange places or unusual circumstances, the Father is not caught by surprise.